"I'm about to go through the AOS (adjustment of status) process. When is the best time to get the medical examination?"
If the alien beneficiary entered on a K1, they should file for adjustment of status after getting married, but before the medical examination expires, which is one year from the time the DS-3025 was issued. If you entered in the United States using a visa other than the K1, then you should be using Form I-693 which has a shorter expiration time. There are differences between the DS-3025 and I-693 medical examination.
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